Day: September 10, 2020

Vaccine developer Moderna could slow COVID-19 trials to add at-risk minorities



a group of people standing in front of a store: FILE PHOTO: FILE PHOTO: Moderna Therapeutics seen during COVID-19 in Massachusetts


© Reuters/Brian Snyder
FILE PHOTO: FILE PHOTO: Moderna Therapeutics seen during COVID-19 in Massachusetts


(Reuters) – Moderna Inc has been asking sites that are conducting clinical trials of its experimental coronavirus vaccine to focus on enrolling at-risk minorities, even if that slows down the trial speed, the company said on Friday.

Shares of Moderna, one of the few companies in the final stages of developing a safe and effective COVID-19 vaccine, fell 6.8% in morning trading.

The drug developer said it expected to enrollment to the late-stage study that began in late-July and aims to add 30,000 healthy volunteers to be completed in September.

As of last week, it had added 17,000 participants, of which nearly 24% are from communities of color.

A growing body of evidence has shown that long-standing health and social inequities have resulted in increased risk of infection and death from COVID-19 among communities of color.

Read More

S.I. boutique fitness studio owners to file lawsuit Wednesday against de Blasio, NYC

STATEN ISLAND, N.Y. — The owners of the Max Challenge — which has three locations on Staten Island — are the lead plaintiffs in a class action lawsuit being filed on Wednesday against Mayor Bill de Blasio and New York City to allow boutique fitness studios to open amid the coronavirus (COVID-19) pandemic, said the lawyer for the case.

The lawsuit, which will be filed Wednesday in Richmond County Supreme Court, St. George., is being led by Roseann and Anthony Camarda, who own three popular fitness studios — in Grasmere, Woodrow and Great Kills — under the Max Challenge franchise on Staten Island, said James G. Mermigis, an attorney with the Syosset, N.Y.-based Mermigis Law Group, who will be filing the case.

“There is absolutely no reason that big box gyms can be open and we can’t,” said Roseann Camarda, who said her membership has been reduced from 1,500 to

Read More

New England Journal of Medicine publishes study results evaluating Ionis antisense therapy in treatment of patients with hereditary angioedema

CARLSBAD, Calif., Sept. 2, 2020 /PRNewswire/ — Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) announced the publication today of the results from a compassionate-use study evaluating IONIS-PKKRx and IONIS-PKK-LRx in patients living with severe bradykinin-mediated angioedema in The New England Journal of Medicine (NEJM). IONIS-PKKRx and IONIS-PKK-LRx are investigational antisense medicines designed to reduce the production of prekallikrein, or PKK, which plays a key role in the activation of inflammatory mediators associated with acute attacks of hereditary angioedema (HAE). In the study, researchers found that the drugs reduced plasma prekallikrein activity levels and showed evidence of clinical efficacy in reducing the number of breakthrough attacks per month in patients over the course of the treatment, including complete resolution in a patient with Type 1 HAE. To view the published study, please visit NEJM.org.

Hereditary angioedema is a rare autosomal dominant disease that results in recurrent, painful attacks

Read More

People experiencing hair loss could benefit from a trip to the dentist

Anyone experiencing sudden patches of hair loss could benefit from a trip to the dentist – according to university research.

Alopecia areata, which affects millions in the UK, is an auto-immune disorder where the body produces antibodies that attack the hair follicles.

The hair loss is often in small patches, which are sometimes barely noticeable. But if these patches join up they can become more obvious and lead to anxiety and loss of self confidence.

Also known as localised alopecia, it is estimated to plague around 65,000 people in the UK and can appear at any age – with 80 per cent of cases surfacing before the age of 40.

Stress is thought to be one one potential trigger, but it appears tooth infections could also be a cause according to research carried out by the University of Granada in Spain.

Lead authors Professor Jose Antonio Gil Montoya and Professor

Read More

Israeli hospital enlists recovered coronavirus patients as volunteers for COVID-19 ward

Hadassah University hospital in Jerusalem is running a pilot program in which recovered coronavirus patients volunteer to help those currently hospitalized with COVID-19, BBC reports.

The hospital’s 30 or so recovered volunteers — who have all been tested to confirm they have antibodies for the virus and wear full protective gear (since it’s still unclear how long immunity lasts) — aren’t performing any medical tasks. Rather, they’re there to lend an ear or sit and talk with patients who would otherwise be in isolation. Dr. Rely Alon, the director of nursing at Hadassah, told BBC that the volunteers are a “great help” for both patients and staff, even if their tasks sound simple.

That’s because, while first and foremost COVID-19 is a deadly disease that may have lasting, harmful affects on the human body, scientists are also concerned about the potential long-term mental health issues that could arise for hospitalized

Read More